Villa vacation rentals in Los Santos Province

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Top-rated villa rentals in Los Santos Province

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An aerial view of a modern, three-bedroom villa nestled among dense green foliage. The structure features a light-colored exterior with a metal roof. A pool area is visible at the back, framed by lush trees, creating a sense of privacy and connection to nature.

Villa in Las Escobas del Venado

4.78 out of 5 average rating, 9 reviews

El Nido, Jungle Villa with Pool at Venao

Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area

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Villa in Playa Venao

5 out of 5 average rating, 3 reviews

Playa Laska – Serene Oceanfront Villa with Pool

Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.

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Guest favorite

An inviting infinity pool extends toward the beach, featuring sleek lounge chairs positioned at the water's edge. Lush greenery surrounds the pool area, while a tall palm tree adds a tropical touch against the backdrop of the ocean and clear blue sky.

Villa in Playa Venao

4.91 out of 5 average rating, 56 reviews

Villa Verde - Luxury & Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

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Guest favorite

A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.

Villa in Cambutal

4.73 out of 5 average rating, 26 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

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A modern living area features a sectional sofa adorned with textured cushions, accompanied by a stylish armchair. A sleek fire feature is mounted on the wall, providing warmth. Natural light flows through large windows, with greenery visible outside, enhancing the space's freshness.

Villa in Las Escobas del Venado

4.86 out of 5 average rating, 14 reviews

Villa Sirena – Blue Venao

Villa Sirena is a modern beach apartment in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

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Guest favorite

A private pool is set within a spacious outdoor area, surrounded by tropical plants and palm trees. The villa's exterior features a covered patio and a beautifully patterned tiled deck, providing an inviting space for relaxation under a clear blue sky.

Villa in PA

4.88 out of 5 average rating, 17 reviews

Casa Colibrí, Pedasi

Immerse yourself in this beautiful custom built villa, within walking distances to one of Pedasi’s best beaches. The villa has many things to offer you from a fully equipped kitchen, private pool, bbq area, along with WIFi. The villa offers a tropical retreat with an ocean view, a covered patio with chairs and table to sit while you enjoy a glass of wine and listen to the sound of the waves crashing. In the evenings sit and relax by the fire pit and listen to the water feature and ocean.

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Villa in Los Santos Province

4.89 out of 5 average rating, 27 reviews

Esplendorosa | Ocean View Villa with Staff & Chef

7 Bedrooms | Up to 16 Guests Luxury Villa with Pool & Ocean View – Staff & Chef Included Welcome to Villa Esplendorosa, a high-end villa located just a short walk from Destiladeros Beach, in Pedasí, Panama. The villa offers an elegant oceanfront setting with on-site staff, ideal for a relaxing and worry-free stay. You will enjoy: • Private swimming pool • Stunning ocean views • Daily staff included (chef & housekeeping until 2:00 pm) • Home cinema area • Power generator and Internet

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Guest favorite

A spacious living area features a modern gray sofa paired with a wooden coffee table, accented by a woven rug. Bright light floods in through large sliding glass doors, which offer a view of the lush garden outside. Bar stools surround a kitchen island in the background.

Villa in Playa Venao

5 out of 5 average rating, 8 reviews

Playa Venao Blue 12 | Luxury Beach Escape Villa

A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.

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Guest favorite

Villa in Las Escobas del Venado

5 out of 5 average rating, 20 reviews

Villa Tortugas, Blue Playa Venao / Beachfront Club

Enjoy a beautiful villa just a three-minute walk from the beach in an exclusive gated community with security and parking. It features two bedrooms with private bathrooms, a guest bathroom, washer and dryer, full kitchen, living room, indoor dining for six, and a spacious terrace with a large dining table and BBQ. Amenities include air conditioning, 130 Mbps Wi-Fi, a 65-inch Smart TV with Apple TV, and access to the oceanfront clubhouse and restaurant.

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An open concept living area showcases a modern kitchen with stainless steel appliances and a welcoming dining space. Natural light floods the room through large sliding glass doors, creating a seamless connection with the outdoor area. The cozy seating arrangement provides a space for relaxation.

Villa in Playa Venao

4.65 out of 5 average rating, 26 reviews

Steps to the Beach 3BR Villa 36 at Playa Venao

Enjoy the beach and relax in Villa-36! This stunning Villa is located in BlueVenao on the Azuero Peninsula, a unique beachfront community and tropical paradise with miles of beautiful beaches. Just a quick walk and you’ll be on the beach, ready for new adventures! Our charming and sunny Villa has 3 bed/3bath, two with a comfy Queen bed, and the third w/twin over full bunk bed. Living, Kitchen and Terrace — Fully equipped for your tropical getaway.

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Villa in Las Tablas

Villa "La Décima" comfortable property to enjoy!

We are located in the spectacular area near to Belisario Porras Park & Church of Santa Librada. Las Tablas City is well known for Carnival celebration, beautiful queens, great float parade, fireworks, music. The Town is a 10 minute walk distance & boasts a wide variety of restaurants, bars and shops. Local activities include: handicrafts, local museum, traditional dance, folklore, Panamenian local food, great rivers and beautiful beaches.

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Guest favorite

A modern villa is seen from the poolside, showcasing a spacious patio area. The building features large glass doors and an overhanging balcony. A serene pool reflects the clear blue sky, bordered by wooden deck and lush greenery in the background.

Villa in Las Escobas del Venado

4.97 out of 5 average rating, 33 reviews

Casa Vida, Breathtaking Ocean View Villa

Casa Vida is a spacious six-bedroom villa perfectly located in the heart of Playa Venao, just minutes from the beach, surf, and restaurants. With breathtaking ocean views, a large private pool, expansive living areas, and modern comforts, it’s ideal for families, groups, or retreats. Concierge service is included to help arrange activities, transport, and everything you need for a seamless stay.

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