Townhome vacation rentals in Pickens County

Find and book unique townhouse rentals on Airbnb

Top-rated townhouse rentals in Pickens County

Guests agree: these townhouse rentals are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1

Top guest favorite

Townhouse in Salem

4.96 out of 5 average rating, 53 reviews

Amenity Rich Keowee Resort - 25 min to Clemson

Enjoy the Best of Both Worlds in our spacious 4-bedroom, 3-bath townhome in the gated Keowee Key Resort. Where lake life, mountain views, and resort amenities come together for the perfect getaway. Spread over three levels with two living rooms and two sunrooms, the home offers plenty of space for families, couples, or friends traveling together. When you're visiting Lake Keowee, Clemson University, or the Blue Ridge Mountains, this home is a comfortable base for both adventure and relaxation.

LocationFamilyHospitality

Top guest favorite

The entrance of a modern resort building is framed by a striking architectural design featuring a large overhanging roof and stone accents. Steps lead up to the glass doors, while landscaped greenery complements the exterior.

Townhouse in Salem

5 out of 5 average rating, 80 reviews

Resort Pool & Spa 3BR 3BTH w Loft, Family Gameroom

Escape to this spacious three-story, family-friendly home w bedrooms, baths, and decks on each level—perfect for large families (sleeps 9). Pack ’n Play available, easy front-door parking, & access to resort pools, spa, and sauna included. It's a professionally cleaned, dog-friendly 3BR, 3BA townhome w loft/3 living spaces. Enjoy wooded rolling hills w wildlife, resort amenities (some activities like golf or boat rentals have fees), ping-pong, board games, and a deck fireplace under the stars.

FamilyLocationWifi

Guest favorite

Townhouse in Easley

4.93 out of 5 average rating, 14 reviews

Walk to Silos | 2BR 2.5BA Townhome + Chef Kitchen

Game-day energy, downtown charm, and your own three-level hideaway—less than 15 minutes from Greenville and 30 minutes from Clemson. Stretch out over king and queen suites, sip coffee on a private balcony, and stroll five minute walk to The Silos food hall before hopping on the Doodle Trail. Welcome to The Bosie, where relaxing weekends and action-packed adventures. Perfect location for game weekends & family visits w/ college kids and business travel! Book your stay before the calendar fills!

LocationFamilyComfort

Guest favorite

A two-story townhome is shown surrounded by a spacious yard with well-maintained grass and trees. The exterior features a blend of light gray siding and brick along with two prominent windows on the ground floor. A garden area with shrubs is visible beside the entrance.

Townhouse in Seneca

5 out of 5 average rating, 8 reviews

Screened Patio Stay for Clemson Weekends & Lakes

3 Mi to Memorial Stadium | Step-Free Entry | Spacious Backyard Turn every Clemson home-game weekend into an easy Upstate getaway at this Seneca vacation rental, just 3 miles from campus and Memorial Stadium. After the final whistle, you can swap the crowds for cornhole in the spacious backyard, dinner on the screened patio, or a movie by the Smart TV, with Lake Keowee and Lake Hartwell nearby for an extra day of adventure. Secure your season-ready home base before the best weekends fill up!

LocationQuietCleanliness

Guest favorite

A two-story townhouse is depicted, featuring a combination of beige siding and dark trim. Large windows allow ample natural light, and a red door adds a pop of color. The surrounding landscape includes a small lawn with trees, showcasing autumn foliage.

Townhouse in Clemson

5 out of 5 average rating, 8 reviews

Brand New Build Clemson Retreat 3br/3bath sleeps 8

This is a new build, two story townhouse. Comfortably sleeps 8. All new furnishings. Kitchen has all that you need to host a football weekend, graduation party or special dinner. All 3 bedrooms have en-suite full bathrooms. Sleeper sofa has Queen gel foam mattress. Kitchen fully stocked. Walking distance to Clemson, and Botanical Gardens. Short drive to restaurants in Patrick Square downtown Clemson and Pendelton. Two parking spaces assigned to house. Truly great location!

LocationAccuracyCheckout

A spacious living area is furnished with comfortable gray sofas and a round coffee table, creating an inviting space. Natural light filters through large windows, illuminating a dining area with wooden chairs. A serene landscape photograph decorates the wall, enhancing the room’s calming ambiance.

Townhouse in Salem

4.71 out of 5 average rating, 14 reviews

Fun Lake Keowee TownHse Golf Tennis Picklball Pool

A lush serene setting of trees, walking paths and nature surround this 3 level townhome within the gates of Keowee Key. You will have quick access to Lake Keowee (2 marinas with kayak and boat launch and boat rentals) Pickle Ball and Tennis courts at the Fitness Center (some additional fees may apply), nearby golf and indoor and outdoor pools. This home is available as a dedicated rental property. The owners do not keep any of their personal items in the home.

LocationSleep qualityComfort

Guest favorite

A large outdoor swimming pool is set against a scenic lakeside backdrop, surrounded by lounge chairs. The water glimmers in sunlight, with trees lining the perimeter. Nearby, a marina with docked boats and a parking area is visible.

Townhouse in Salem

5 out of 5 average rating, 12 reviews

Walk to Lake Keowee: Salem Townhome w/ Deck

Walk to Private Beach | Fireplace | Newly Renovated | 10 Mi to Clemson Escape to this 4-bedroom, 3-bath vacation rental in Salem! Perfect for families, this townhome offers ample space to unwind after exploring Lake Keowee or Table Rock State Park. With a full kitchen and access to community amenities, this townhome has everything you need for a memorable retreat! Be sure to relax by the community pool or play a round of golf before cozying up by the fireplace!

FamilyLocationView

The exterior of a two-story townhouse is showcased, featuring blue-gray siding and contrasting black shutters. A bright yellow front door is positioned above a small mat, while a two-car garage with white doors is seen on the right. Landscaping includes dark mulch and small plants.

Townhouse in Easley

5 out of 5 average rating, 3 reviews

Exclusive Luxury Escape

Welcome to this cozy place in Easley, SC—perfectly located between Clemson and Greenville! Just 20 minutes from Clemson University and downtown Greenville, this space is ideal for college visits, game days, or exploring the Upstate. Enjoy a quiet, comfortable stay with modern amenities and easy access to local dining, shopping, and outdoor activities. Whether you're here for a Tigers game or a weekend getaway, our home offers the perfect base for your adventure.

LocationValueQuiet

Guest favorite

Townhouse in Seneca

5 out of 5 average rating, 8 reviews

Boat Dock: Lake-View Retreat 5 Mi to Dtwn Clemson

Whether you're here for a relaxing lakefront getaway or to cheer on the Tigers, this impressive Seneca house is the perfect choice for you! Ideally situated on a private lot of nearly one acre on picturesque Lake Hartwell, this vacation rental boasts ample deck space, three screened porches, and a media room perfect for watching the big game. You'll love being within four miles of Clemson University, museums, parks, shops, restaurants, and more!

FamilyLocationOutdoor spaces

Superhost

The exterior of the townhouse features a neutral brown wood paneling along with a brick chimney. A welcoming front porch with white railings leads up to the front door. The surrounding area includes neatly trimmed bushes and a backdrop of greenery, indicating a peaceful community setting.

Townhouse in Clemson

4.88 out of 5 average rating, 16 reviews

Rosehill Villa at Clemson Botanical Gardens

Newly renovated 4 bedroom 3.5 bathroom townhouse. Open concept kitchen, living room and dining room. Small deck located off the kitchen and dining room to relax with coffee. Bring the whole family to this great place with lots of room for fun. This property backs up to the Clemson Botanical Gardens and is a 5 minute drive to reach Memorial Stadium (football), Littlejohn Coliseum (basketball), all where the Tigers play.

ValueFamilyLayout

Superhost

A modern townhouse exterior is presented, featuring a mix of blue and gray siding. A neatly maintained driveway leads to the garage. Green grass blankets the front yard, and landscaping beds enhance the curb appeal with low-maintenance plants.

Townhouse in Central

5 out of 5 average rating, 3 reviews

Tiger Nest in Clemson, SC!

Tiger Nest - Luxury Townhouse Retreat in Clemson, SC Welcome to your perfect getaway! Our high-end townhouse, newly constructed and nestled in a serene neighborhood just outside of Clemson, SC, is your ideal home away from home. Designed with elegance and comfort in mind, this spacious and modern property offers everything you need for a relaxing and memorable stay.

FamilyCleanliness

Top guest favorite

Townhouse in Clemson

4.98 out of 5 average rating, 43 reviews

TigerTown HideAway

Perfect spot for your visit to Clemson. 4 bedroom/4.5 bathroom close to everything. Property backs up to Clemson’s Botanical Gardens. Beautiful Lake Keowee and Hartwell is a short drive away. Lake Jocasse is about an hours drive. 2 minute drive to downtown. Near restaurants and grocery stores. This townhome can sleep 10+ Anderson - 15 min Greenville -45 min

LocationFamilyOutdoor spaces