
Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.

Spacious, Over the Water Home with Plunge Pool
Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.
LocationFamilyLaundry

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool
➡️ The highest rated w more than 60 reviews! ⬅️ Welcome to "The Gliding Damselfly," the MOST stylish 4BR 4Bath flat nestled in the majestic Buenaventura, perfect for escaping city crowds and enjoying mesmerizing views, stunning beaches (5 mins), and lavish pools (2 mins). Explore the area and its exciting attractions, and then retreat to the breathtaking sanctuary that will leave you in awe. ✔ 4 Comfy BRs ✔ Open Design Living ✔ Full Kitchen ✔ Terrace ✔ Smart TVs ✔ Fast Wi-Fi See more below!
LocationFamilySleep quality

Costa Blanca Beach & Golf Villa by Decameron
Spacious Villa with Pool, Golf Views & Beach Access Relax in this stylish 4-bedroom villa overlooking the 7th putting green of Mantarraya Golf Course. All on one level, it offers 250 sq m of comfort, with en-suite bathrooms and space for up to 12 guests. Wow ! - Private 15 m pool with shallow area - 15-minute walk to Pacific beach - Access to Owners Beach Club (restaurant + parking) - Peaceful golf course setting Perfect for families, groups, or golf lovers seeking sun and serenity.
FamilyLocationCondition

Casa Coco - Beautiful Mountain Villa With AC
Elegant and modern, our home strikes the perfect balance between luxury and warmth. With ample space to accommodate large groups and families, as well as cozy and inviting for smaller groups. The yard features a covered social area, ideal for relaxing or entertaining. A lush garden adorned with vibrant greenery includes a charming mango tree and mountain peak views. A 5 minute walk to restaurants and the open air market. If you have a group larger than 12- please reach out to us directly.
FamilyValueView

Beach House with Pool/Gazebo in Punta Chame!
"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"
FamilyLocationSleep quality

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.
LocationValueOutdoor spaces

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.
FamilyLocationAmenities

Cozy Lagoon View Apartment | BBQ
Un espacio amplio y tranquilo en buenaventura con capacidad para (10) personas, donde podrán disfrutar de una barbacoa en su amplia terraza y su hermosa vista al Lago. Con 190m este hermoso apartamento cuenta con: - 4 dormitorios. - 4 baños completos. - Cocina completa. - Sala. - Comedor. - Terraza con parilla para barcacoa, abanico, sillas y sillones exteriores. - Área de Lavandería. - Dos (2) Estacionamientos. - Área para bicicletas o motos.
LocationFamilyIndoor spaces

Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.
ValueLocationAccuracy

BirdHouse — Gamboa, Panama Canal Rainforest
BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.
FamilyValueWalkability

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.
Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.
ValueFamilyIndoor spaces

Infinity Pool Boutique Villa on The Point Break
Our Private Boutique Style Yoga and Surf Villa features comfortable rooms, many with unobstructed ocean views. Each room is airconditioned with a private bathroom. Our guests are like family, spend downtime between yoga, surf, and the infinity pool, relishing spectacular sunset views.
FamilyLocationLaundry
Popular amenities for Panama mansion rentals
Luxury mansion rentals

Luxury beachfront villa!
ValueFamilyKitchen

La Casa de la Cascada has a bbq, ping pong, and a gym
ValueFamilyComfort

Mansion on Organic Farm with Heated Pool
LocationFamilyCondition

Your perfect mountain escape
FamilyLocationCondition

Luxury Beachfront Escape | Playa Escondida Resort
LocationFamilyCleanliness

Villa Papagayo, Morrillo Beach, Veraguas
ValueLocationView

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura
ValueFamilyOutdoor spaces

Modern Luxury Beach Front House in Coronado
ValueLocationAir conditioning
Pet-friendly mansion rentals

Mountain Retreat
FamilyValueAccess

Entire Villa with pool in front of beach!
ValueFamilyAccuracy

Escultura 2 — 4BR/4BA w/AC, near surf and beach
FamilyLocationQuiet

Exclusive Villa with pool, and beach minutes away
FamilyLocationDecor

Villa GiGi - Beach Home Panama Santa Clara
LocationFamilyNearby

Exclusive apartment steps from the sea in Puntarena
FamilyValueCleanliness

Spectacular Beachfront House
LocationFamilyAmenities

Luxurious country house, pleasant climate, with fireplace, jacuzzi, pool table, barbecue area, fire pit and more...
LocationFamilyAir conditioning
Mansion rentals with a pool

Playa Escondida with the Best Direct Ocean View
ValueLocationLaundry

Nice duplex house with a swimming pool.
LocationFamilyGrill

Beachfront Home | En-Suites + Chef & Tours Available
FamilyLocationGetting around

Cottage + Pool + Wi-Fi + AC + Beach @Playalosdestiladeros
LocationFamilyHospitality

Cerro Azul, Country House with Heated Pool.
LocationFamilyShared spaces

Blue Mountains Cabin
LocationFamilyIndoor spaces

Jungle House 100m from the beach
LocationFamilyPool

24o Penthouse, Unique Design, 2 Balconies, Ocean View
FamilyLocationSleep quality
Destinations to explore
- Lakehouse rentals Panama
- Pet-friendly rentals Panama
- Beach condo rentals Panama
- Rentals with breakfast Panama
- Rentals with an accessible height bed Panama
- Aparthotel rentals Panama
- Hotel rooms Panama
- Earth house rentals Panama
- Private suite rentals Panama
- Rentals with a sauna Panama
- Nature eco lodge rentals Panama
- Rentals with beach access Panama
- Chalet rentals Panama
- Loft rentals Panama
- Bungalow rentals Panama
- Bed and breakfasts Panama
- Boutique hotels Panama
- Shipping container rentals Panama
- Tent rentals Panama
- Cottage rentals Panama
- Townhouse rentals Panama
- Cabin rentals Panama
- Hostel rentals Panama
- Vacation home rentals Panama
- Family-friendly rentals Panama
- Treehouse rentals Panama
- Dome rentals Panama
- Condo rentals Panama
- Rentals with lake access Panama
- Apartment rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- House rentals Panama
- Rentals with a hot tub Panama
- Farmstay rentals Panama
- Beach house rentals Panama
- Guesthouse rentals Panama
- Island rentals Panama
- Villa rentals Panama
- Waterfront rentals Panama
- Boat rentals Panama
- Tiny house rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Rentals with pools Panama
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes





