Guesthouse vacation rentals in Panama

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Panama

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A charming cottage with a red metal roof is surrounded by lush greenery and colorful flowers. A few small trees and plants frame the image, highlighting the tranquil garden setting and the natural beauty of the hillside location.

Guesthouse in Los Naranjos

4.92 out of 5 average rating, 263 reviews

Sunshine Cottage at Finca Katrina

Sunshine Cottage is a little cottage in the back garden of Finca Katrina. It is set on a hill with views of Palo Alto and Jaramillo with a coffee plantation in the foreground. There is a full (double) bed, room to hang your clothes and to store your belongings. You have a small fridge, toaster oven, sink, coffee maker, and cupboard space for food, but no stove top. If you are looking for more bedrooms, there are additional units on Finca Katrina that compliment Sunshine Cottage. Send us a note!

LocationValueOutdoor spaces

Top guest favorite

The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.

Guesthouse in El Valle de Antón

4.99 out of 5 average rating, 131 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

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Guest favorite

Guesthouse in El Valle de Antón

4.91 out of 5 average rating, 112 reviews

The Retreat in El Valle - Casita de la Montaña

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features two rooms, including a queen bed, choice of king or twin beds, a small fridge, coffee station, Wi-Fi, and large terrace with comfy couch. Enjoy the shared pool, book meditation/ healing sessions, explore world-class hiking. Enjoy next door La Compania restaurants, El Valle’s famous artisan market!

ValueFamilyAir conditioning

Top guest favorite

A charming apartment building is nestled among lush greenery and tall trees. The exterior features a welcoming porch with railings and is surrounded by tropical plants, creating a serene environment. Natural sunlight filters through the leaves, highlighting the vibrant foliage.

Guesthouse in Gamboa

4.94 out of 5 average rating, 86 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

ValueLocationNearby

Top guest favorite

A serene view from the guesthouse showcases a private balcony with two chairs and a small table, positioned before lush greenery and distant mountains. The inviting landscape is framed by the sliding glass doors, enhancing the connection to nature.

Guesthouse in Torio

4.92 out of 5 average rating, 155 reviews

Torio guesthouse with panoramic view; Kokomo

Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

LocationFamilyBathroom

Top guest favorite

A tranquil outdoor area is depicted, featuring a small private pool surrounded by lush greenery. The charming cottage stands nearby, characterized by large windows and a covered porch that offers ample natural light.

Guesthouse in Panamá Oeste

4.81 out of 5 average rating, 196 reviews

Cabaña de montaña con piscina privada en Panamá

Disfruta de la paz y la naturaleza en esta acogedora y equipada cabaña, perfecta para desconectar y relajarte. Rodeado de bosques y con vistas espectaculares, aquí podrás respirar aire puro y contemplar las estrellas. ✔️ Ideal para parejas, familias o aventureros. ✔️ Senderos, ríos y miradores cercanos. ✔️ Espacios cómodos y equipados para tu confort. - Capacidad de 4 personas. - Descuento a partir de dos noches. Cerca a: Laguna de San Carlos, Valle de Antón, playas del Pacifico Panameño.

FamilyValuePool

Top guest favorite

The property is illuminated at night, showcasing a spacious terrace with comfortable furniture. Soft lighting highlights the structure's features, while stairs lead to the lower level. A serene atmosphere is created by the surrounding trees and dark sky.

Guesthouse in Mariato

4.97 out of 5 average rating, 93 reviews

Beachfront Nature Rentals, Full floor Studio

At Beachfront Nature Rentals we have a 1km beautiful sandy beach. STARLINK, Solar power, Peace & Quiet. 4 wheel drive car is not required. Soft rhythmic sound of the waves. Every week; new birds, turtles nesting, dolphins, whales or monkeys. See the stars without light pollution. Ocean is perfect for swimming and body-boarding. Swim in our pool anytime you like. We have walking or driving access to a surfing beach. For DIGITAL NOMADS, a desk, good wifi, work on the terrace, Rancho or beach.

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Guest favorite

A private swimming pool with a waterfall is surrounded by lush greenery, providing a tranquil setting. A thatched-roof structure is visible nearby, creating an inviting space for relaxation. Colorful flowers and plants enhance the outdoor area, making it suitable for leisurely outdoor dining.

Guesthouse in Rio Hato

4.9 out of 5 average rating, 126 reviews

Sustainable Guest house with Pool in Rio Hato

Discover Rancho Ahome, a serene 2BR 1Bath guesthouse in Rio Hato. Escape to tranquility, 5 mins from stunning beaches, and enjoy our private pool with a waterfall. Immerse in nature on our sustainable farm, home to fruits, rabbits and chickens. Perfect for those seeking peace and an eco-friendly retreat, Rancho Ahome offers a blend of comfort and adventure amidst breathtaking landscapes. Experience a peaceful sanctuary that’s close to nature yet filled with comfort. We are pet friendly.

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Top guest favorite

Guesthouse in Jaramillo

4.96 out of 5 average rating, 25 reviews

Bambu Cabaña

Take it easy at this unique and tranquil getaway. The Bambu Cabana is surrounded by bamboo and features a unobstructed view of Vulcan Baru. Wake up to see the sun reflecting off of the mountain, visible clearly through large floor to ceiling wrap around windows. Do some work at the desk or relax in the recliners or outdoor balcony chairs. Enjoy a refreshing shower or long soak in the large bathtub. The cabana includes a well stocked kitchenette, and washer dryer combo.

LocationValueIndoor spaces

Top guest favorite

Guesthouse in Cambutal

5 out of 5 average rating, 14 reviews

Casita Verde 411 Surf Cambutal

Your private jungle hideaway by the ocean. Wake up to the sound of waves and tropical birds, just a 3-min walk from the surf. Step outside into lush greenery, slow down, and feel more present. A quiet place to surf, relax, and reconnect – far from crowds, surrounded by nature and ocean. Spend your mornings in the water, unwind in the hammock, and enjoy stargazing at night. Perfect for longer stays, remote work, or anyone looking for a slower, grounded way of living.

LocationFamilyIndoor spaces

Guest favorite

A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.

Guesthouse in Panamá

4.86 out of 5 average rating, 138 reviews

Casa de huésped privada en Ancón

Disfruta de la sencillez de este acogedor alojamiento tranquilo y céntrico. Cerca de lugares de interés como el edificio de la Administración del Canal de Panamá, Amador Causeway, Albrook Mall, y varios restaurantes. Personalmente decorado para proporcionar comodidad... grandes ventanales en el dormitorio proporcionan iluminación natural y una vista del jardín y el área verde a través de las ventanas; aun así mantiene la privacidad y la tranquilidad deseada.

ValueLocationTV

Top guest favorite

Guesthouse in El Valle de Antón

4.93 out of 5 average rating, 60 reviews

Cabaña Flor del Aire

Bienvenidos a nuestra cabaña Flor del Aire. Un refugio privado y acogedor, hasta para 3 personas. La cabaña está rodeada de un gran jardín donde podrás disfrutar de la biodiversidad local. Contamos con una cocina bien equipada y ducha con agua caliente. *Estacionamiento privado. *Espacio libre de Wi-Fi, una oportunidad ideal para desconectarse. Para quienes necesiten Wi-Fi hay un excelente coffee shop a pocos metros de distancia. *Somos pet friendly.

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